The exact cause of CRC is unknown although various risk factors are known to increase one’s risk for developing the disease. Approximately 90% are sporadic cases arising from multi interaction of factors such as aging, male gender or environmental and lifestyle factors while up to 10% are caused by unknown or known inherited changes (mutations) in genes responsible for cancer formation and progression. In general one has twice likelihood to develop CRC if there is a single-family history in a first-degree relative. Stronger risk is observed in immediate family members of a patient with history of CRC or adenomatous polyps diagnosed at age younger than 60; or a similar history in two or more first-degree relatives diagnosed at any age. The reasons for the increased risk are not clear, but it likely due to inherited genes, shared environmental factors, or some combination of these.
Aging process increases the risk for CRC with more than 70% of patients with being 65 years or older. People who suer from inflammatory bowel disease such as Ulcerative colitis and Crohn’s disease, characterized by chronic inflammation of the gut mucosa have a 4- to 20-fold relative risk of developing CRC thus they can be routinely checked by their doctors for early cancer detection.
Environmental and lifestyle risk factors related to a Westernized diet, high consumption of red meat and animal fat especially when it is highly processed or cooked in high temperature have been implicated for CRC.
To find out more, or to discuss your wider healthcare needs, please contact us:
T: +603 5639 1212
Subang Jaya Medical Centre
1, Jalan SS12/1A, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia.